Antitrypanosomal activity of some pregnane glycosides isolated from Caralluma species.
نویسندگان
چکیده
Pregnane glycosides previously isolated from genus Caralluma (C. Penicillata, C. tuberculata and C. russelliana) were tested for their antitrypanosomal activity. Penicilloside E showed the highest antitrypanosomal activity (IC(50) 1.01 microg/ml) followed by caratuberside C (IC(50) 1.85 microg/ml), which exhibited the highest selectivity index (SI 12.04). It was noticed that acylation is required for the antitrypanosomal activity while glycosylation at C-20 has no significant effect on the activity.
منابع مشابه
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ورودعنوان ژورنال:
- Phytomedicine : international journal of phytotherapy and phytopharmacology
دوره 16 6-7 شماره
صفحات -
تاریخ انتشار 2009